寻因生物已发表文章列表
作者: 高瑞峰
时长: 111 分钟
字数: 23.8k 字
更新: 2025-09-17
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下面展示所有项目文章，支持按年份、产品类型、影响因子区间筛选，按影响因子和年份排序展示，以及关键词搜索。表格可导出为 CSV，DOI 可直接打开原文链接。
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| 年份 | 文章标题 | 期刊名称 | 影响因子 | 样品类型 | 产品类型 | DOI | 文章解读 |
|---|---|---|---|---|---|---|---|
| 2023 | Single-cell transcriptome analysis profiles cellular and molecular alterations in submandibular gland and blood in IgG4-related disease | Annals of the Rheumatic Diseases | 27.4 | PBMC和颌下腺组织 | SeekOne MM 单细胞 3′转录组 | https://doi.org/10.1136/ard-2023-224363 | |
| 2024 | Janus liposozyme for the modulation of redox and immune homeostasis in infected diabetic wounds | Nature Nanotechnology | 38.3 | 小鼠皮肤伤口 | SeekOne DD 单细胞 3′转录组，SeekSoul Online云平台 | https://doi.org/10.1038/s41565-024-01660-y | 2024年5月，寻因生物单细胞转录组产品助力南开大学研究团队在《Nat. Nanotechnol》发表题为“Janus liposozyme for the modulation of redox and immune homeostasis in infected diabetic wounds”的文章。寻因生物提供了单细胞转录组（scRNA-seq）测序和基于SeekSoul Online云平台的数据分析服务。 查看解读 |
| 2024 | Computing cell state discriminates the aberrant hematopoiesis and activated microenvironment in Myelodysplastic syndrome (MDS) through a single cell genomic study | Journal of Translational Medicine | 6.1 | 骨髓细胞 | SeekOne DD 单细胞 3′转录组 | https://doi.org/10.1186/s12967-024-05496-x | |
| 2024 | Integrative profiling of untreated primary membranous nephropathy at the single-cell transcriptome level | Clinical Kidney Journal | 3.9 | PMN患者血液、肾脏和尿液 | SeekOne MM 单细胞 3′转录组 | https://doi.org/10.1093/ckj/sfae168 | |
| 2024 | Cooperative progression of colitis and leukemia modulated by clonal hematopoiesis via PTX3/IL-1β pro-inflammatory signaling | Genes & Diseases | 6.9 | 小鼠结肠组织的细胞 | 其他 | https://doi.org/10.1101/2023.08.29.555330 | |
| 2024 | A distinct immune landscape in anti-synthetase syndrome profiled by a single-cell genomic study | Frontiers in Immunology | 5.7 | PBMC | SeekOne MM 单细胞 3′转录组 | https://doi.org/10.3389/fimmu.2024.1436114 | |
| 2025 | Utilization of donor CLL-1 CAR-T cells for the treatment of relapsed of acute myeloid leukemia following allogeneic hematopoietic stem cell transplantation | Frontiers in Immunology | 5.7 | 患者 4 的 CLL-1 CAR-T 细胞输注产品及外周血单个核细胞（PBMCs）在扩增峰值时的细胞 | SeekOne DD 单细胞 3′转录组 | https://doi.org/10.3389/fimmu.2024.1491341 | |
| 2025 | Single-cell and spatial transcriptomics reveal the pathogenesis of chronic granulomatous disease in a natural model | Cell Reports | 7.5 | 肺组织 | SeekSpace 单细胞空间转录组 | https://doi.org/10.1016/j.celrep.2025.115612 | |
| 2025 | Longitudinal Changes in Peripheral and Alveolar Monocyte and Inflammatory Biomarkers are Distinct in Hypercapnia Patients Following Pulmonary Sepsis-Induced ARDS | Journal of Inflammation Research | 4.2 | 外周血 | SeekOne DD 单细胞 5′转录组 | https://doi.org/10.2147/JIR.S508311 | |
| 2025 | Myeloid-lineage-specific membrane protein LRRC25 suppresses immunity in solid tumor and is a potential cancer immunotherapy checkpoint target | Cell Reports | 7.5 | 小鼠多种癌组织 | 其他 | https://doi.org/10.1016/j.celrep.2025.115631 | |
| 2025 | Single-cell profiling reveals monocyte heterogeneity and association with liver fibrosis in patients with chronic HBV | Hepatology Communications | 5.6 | 外周血 | SeekSoul Online云平台 | https://doi.org/10.1097/HC9.0000000000000672 | |
| 2025 | Cooperative progression of colitis and leukemia modulated by clonal hematopoiesis via PTX3/IL-1β pro-inflammatory signaling | Genes & Diseases | 9.4 | 小鼠结肠组织 | 其他 | https://doi.org/10.1016/j.gendis.2024.101397 | |
| 2025 | Single-cell atlas reveals heterogeneous response to FcRn blockade in anti-AChR antibody-positive generalised myasthenia gravis | Clinical and Translational Medicine | 6.8 | PBMC | SeekOne DD 单细胞 3′转录组 | https://doi.org/10.1002/ctm2.70436 | |
| 2025 | Nociceptor neurons promote PDAC progression and cancer pain by interaction with cancer-associated fibroblasts and suppression of natural killer cells | Cell Research | 28.1 | 胰腺导管腺癌组织 | SeekOne DD 单细胞 3′转录组 | https://doi.org/10.1038/s41422-025-01098-4 | |
| 2024 | CXCR6 defines therapeutic subtypes of CD4+ cytotoxic T cell lineage for adoptive cell transfer therapy in pediatric B cell acute lymphoblastic leukemia | International Immunopharmacology | 4.8 | 外周血和骨髓样本， | SeekOne DD 单细胞 3′转录组 | https://doi.org/10.1016/j.intimp.2024.111972 | |
| 2025 | Rational Design and Organoid-Based Evaluation of a Cocktail CAR-γδ T Cell Therapy for Heterogeneous Glioblastoma | Advanced Science | 14.3 | 胶质母细胞瘤 | SeekOne MM 单细胞 3′转录组 | https://doi.org/10.1002/advs.202501772 | |
| 2023 | Efficacy, Mechanism, and Structure−Activity Relationship of 6‑Methoxy Benzofuran Derivatives as a Useful Tool for Senile Osteoporosis | Journal of Medicinal Chemistry | 7.3 | 骨质疏松 | SeekOne MM 单细胞 3′转录组 | https://doi.org/10.1021/acs.jmedchem.2c01377 | 中国医学科学院北京协和医学院-医药生物技术研究所在 《Journal of Medicinal Chemistry》 上发表题为 《Efficacy, Mechanism, and Structure−Activity Relationship of 6‑Methoxy Benzofuran Derivatives as a Useful Tool for Senile Osteoporosis》的文章，第一作者为周子颖，通讯作者为李卓荣研究员和薛司徒副研究员。本文采用 C57 和 SAMP‑6 老年小鼠模型，探讨 6‑甲氧基苯并呋喃衍生物 125对老年骨质疏松症（SOP）的治疗与预防作用。单细胞转录组分析显示 BMP2 上调是 125 加速骨转换和增加成骨细胞比例的机制。本研究为SOP类药物的开发提供了基础。北京寻因生物为其提供了单细胞转录组测序和分析服务。寻因 SeekOne® MM单细胞转录组助力验证小分子药物 125 通过 PERK‑eIF2α‑ATF4 调节骨形成。 查看解读 |
| 2023 | Single-cell RNA sequencing reveals intratumoral heterogeneity and potential mechanisms of malignant progression in prostate cancer with perineural invasion | Frontiers in Genetics | 3.7 | 前列腺癌 | SeekOne MM 单细胞 3′转录组 | https://doi.org/10.3389/fgene.2022.1073232 | |
| 2023 | Liver macrophages show an immunotolerance phenotype in nonalcoholic fatty liver combined with Porphyromonas gingivalis-lipopolysaccharide infection | 华西口腔医学杂志 | 1.3 | 小鼠肝脏 | SeekOne MM 单细胞 3′转录组 | https://doi.org/10.7518/hxkq.2023.2023111 | |
| 2024 | Network-based screening identifies sitagliptin as an antitumor drug targeting dendritic cells | J Immunother Cancer | 10.9 | 对照/药物处理肿瘤 | SeekOne DD 单细胞 5′转录组 | https://doi.org/10.1136/jitc-2023-008254 | |
| 2024 | BMP2–ERK–ATF4 Axis-Based 6-methoxybenzofuran Compound I-9 Acts as Candidate Drug for Bone Formation and Anti-Osteoporosis | International Journal of Molecular Sciences | 4.9 | 股骨 | SeekOne MM 单细胞 3'转录组 | https://doi.org/10.3390/ijms25063350 | |
| 2024 | Multi-omic analysis identifies metabolic biomarkers for the early detection of breast cancer and therapeutic response prediction | iScience | 4.6 | 乳腺癌/癌旁 | SeekOne MM 单细胞 3'转录组 | https://doi.org/10.1016/j.isci.2024.110682 | |
| 2024 | TLR agonists promote formation of Tertiary Lymphoid Structure and improve anti-glioma immunity | Neuro-Oncology | 16.4 | 鼠胶质瘤细胞 | SeekOne DD 单细胞 5′转录组 | https://doi.org/10.1093/neuonc/noae167 | |
| 2024 | Immunosuppression and phenotypic plasticity in an atlas of human hepatocholangiocarcinoma | Hepatobiliary Surgery and Nutrition | 6.1 | 肝肿瘤 | SeekOne MM 单细胞 3'转录组 | https://doi.org/10.21037/hbsn-23-400 | |
| 2024 | Neoadjuvant toripalimab plus axitinib for clear cell renal cell carcinoma with inferior vena cava tumor thrombus: NEOTAX, a phase 2 study | Signal Transduct Target Ther | 40.8 | 肿瘤血栓 | SeekOne MM 单细胞 3'转录组 | https://doi.org/10.1038/s41392-024-01990-2 | |
| 2024 | Cellular and molecular landscape of primary dermatofibrosarcoma protuberans: Insights from single‐cell RNA sequencing analysis | Exp Dermatol | 3.5 | 肩部肿瘤结节 | SeekOne DD 单细胞 3′转录组 | https://doi.org/10.1111/exd.15121 | |
| 2024 | PD - L1 protects tumor - associated dendritic cells from ferroptosis during immunogenic chemotherapy | Cell Reports | 7.5 | 鼠肿瘤模型中引流淋巴结（dLNs）的 T 细胞 | SeekOne DD 单细胞 5′转录组 | https://doi.org/10.1016/j.celrep.2024.114868 | |
| 2024 | Lung Single-Cell Transcriptomics Offers Insights into the Pulmonary Interstitial Toxicity Caused by Silica Nanoparticles | Environment & Health | 5.3 | 大鼠肺组织 | SeekOne DD 单细胞 3′转录组 | https://doi.org/10.1021/envhealth.4c00052 | |
| 2024 | Single - cell transcriptomic analysis reveals regulative mechanisms of follicular selection and atresia in chicken granulosa cells | Food Research International | 7 | 鸡卵泡颗粒细胞层的细胞 | SeekOne MM 单细胞 3'转录组 | https://doi.org/10.1016/j.foodres.2024.115368 | |
| 2025 | Transcriptomic Profiling Unveils EDN3+ Meningeal Fibroblasts as Key Players in Sturge-Weber Syndrome Pathogenesis | Advanced Science | 14.3 | 斯特奇 - 韦伯综合征（SWS）患者脑部的畸形组织（SWS 样本）和病灶周围组织（对照样本）中的细胞1 | SeekOne DD 单细胞 3′转录组 | https://doi.org/10.1002/advs.202408888 | Sturge‑Weber 综合征（SWS）又称脑面血管瘤病，又称脑面血管瘤病，其特点是脑膜血管畸形，导致危及生命的癫痫发作和中风的重大风险。由于目前缺乏特异性治疗的药物，亟需深入了解驱动SWS进展的分子和细胞机制，为未来的治疗干预提供潜在的靶点。2025年2月10日，首都医科大学三博脑科医院栾国明、关宇光团队与北京脑科学与类脑研究所戈鹉平团队合作在 《Advanced Science》 发表 《Transcriptomic Profiling Unveils EDN3+ Meningeal Fibroblasts as Key Players in Sturge‑Weber Syndrome Pathogenesis》。研究基于 SWS 患者畸形脑组织与病灶周围组织，解析了复杂的细胞异质性，揭示了与疾病进展相关的不同细胞亚状态，并确定了促进 SWS 发展的 EDN3+ 脑膜成纤维细胞及其分子机制，为未来治疗干预提供潜在靶点。北京寻因生物在本项目中提供了专业的单细胞转录组测序服务-SeekOne® MM平台，确保研究团队获得高质量的单细胞转录组数据。 查看解读 |
| 2025 | Epitope‑focused vaccine immunogens design using tailored horseshoe‑shaped scaffold | Journal of Nanobiotechnology | 10.6 | 免疫后的小鼠脾脏中的 B 细胞 | SeekOne DD 单细胞 5′转录组 + VDJ | https://doi.org/10.1186/s12951-025-03200-9 | |
| 2025 | Splicing diversity enhances the molecular classification of pituitary neuroendocrine tumors | Nature Communications | 14.4 | 垂体神经内分泌肿瘤（包括 GH、PG、PRL、TSH、ACTH、GO、NULL 亚型）及正常垂体组织 | SeekOne DD 单细胞全序列转录组 | https://doi.org/10.1038/s41467-025-56821-x | 垂体神经内分泌瘤（PitNETs）是最常见的颅内肿瘤之一，临床表现多样。目前的病理学分类系统主要依赖于组织学激素染色和转录因子（TFs）表达。虽然可以有效地识别三个主要谱系，但基于激素和TF的分子特征缺乏足够的分辨率来完全捕获复杂的肿瘤异质性。2025年2月11日，北京市神经外科研究所/天坛医院谢微嫣、李储忠团队及国家生物信息中心计算生物学部刘肇祺团队研究人员在Nature communications上发表了文章Splicing diversity enhances the molecular classification of pituitary neuroendocrine tumors，研究人员通过对264例PitNET患者和4例正常样本进行bulk RNA测序，以及对14例PitNET患者和2例正常样本进行单细胞全长RNA测序，全面调查了所有PitNET谱系中的选择性剪接（AS）失调情况。本研究有效地区分了沉默性促肾上腺皮质激素亚型并定义了一个独特的TPIT 谱系亚型，这与 ESRP1 表达改变驱动的较差临床结果和剪接异常增加有关。这些结果表征了PitNETs 中亚型特异性AS景观，增强了对PitNETs亚型的理解。 查看解读 |
| 2025 | Single-cell transcriptome analysis reveals cellular heterogeneity in the aortas of Takayasu arteritis | Arthritis Research & Therapy | 4.4 | 主动脉组织 | SeekOne MM 单细胞 3'转录组 | https://doi.org/10.1186/s13075-025-03523-w | |
| 2025 | Single-cell transcriptome analysis reveals cellular heterogeneity in the aortas of Takayasu arteritis | Arthritis Research & Therapy | 4.4 | 主动脉组织 | SeekOne MM 单细胞 3'转录组 | https://doi.org/10.1186/s13075-025-03523-w | |
| 2025 | A skin organoid-based infection platform identifies an inhibitor specific for HFMD | Nature Communications | 14.7 | 皮肤类器官 | SeekOne MM 单细胞 3'转录组 | https://doi.org/10.1038/s41467-025-57610-2 | EV-A71是手足口病（HFMD）的主要病原体，可通过直接和间接的皮肤接触传播，严重威胁儿童健康甚至生命，因此迫切需要使用人源细胞创建新的皮肤模型，以研究病毒的生物学和发病机制，促进药物筛选。2025年3月13日中国医学科学院北京协和医院冷泠团队在Nature Communications杂志上发表了题为《A skin organoid-based infection platform identifies an inhibitor specific for HFMD》的论文。本研究创建了人诱导多能干细胞来源的皮肤类器官（hiPSC-SOs）感染模型，利用单细胞转录组测序和蛋白质组学等技术，研究发现EV-A71可以通过自噬和 Integrin/Hippo-YAP/TAZ 信号通路介导表皮细胞损伤，从而促进祖细胞的过度增殖。基于该发现，确定了一种自噬相关蛋白作为EV-A71的药物靶标，并发现了一种EVA71复制抑制剂为手足口疾病的临床治疗提供了新的有益方向。 查看解读 |
| 2025 | Microglial MS4A4A Protects against Epileptic Seizures in Alzheimer’s Disease | Advanced Science | 14.3 | 结节性硬化症病灶及周围脑组织 | SeekOne DD 单细胞 3′转录组 | https://doi.org/10.1002/advs.202417733 | 阿尔茨海默病（AD）是全球最常见的神经退行性疾病之一，癫痫发作是其常见并发症之一，有研究发现癫痫的发作会加重患者认知功能衰退，强调了早期治疗干预拥有极大的潜力。然而，调节AD中癫痫发作发展的潜在机制仍然没有得到充分理解，这阻碍了转化研究的进展。2025年5月11日，清华大学免疫学研究所、基础医学院曾文文教授课题组与北京大学第一医院蔡立新/孙宇团队、清华大学罗茂国合作研究，于《Advanced Science》杂志在线发表题为《Microglial MS4A4A Protects against Epileptic Seizures in Alzheimer's Disease》的研究论文，首次揭示小胶质细胞MS4A4A在阿尔茨海默病（AD）癫痫发作中的重要作用，为AD相关治疗提供新靶点。北京寻因生物在本项目中提供了专业的单细胞转录组测序服务-SeekOne® DD平台，确保研究团队获得高质量的单细胞转录组数据。 查看解读 |
| 2025 | Predictive factors for neoadjuvant combined immunotherapy in gastric adenocarcinoma: Focusing on the primitive enterocyte phenotype and PVR | British Journal of Cancer | 6.4 | 胃腺癌 | SeekOne DD FFPE 单细胞转录组 | https://doi.org/10.1038/s41416-025-03031-3 | |
| 2025 | Reading of Human Acute Immune Dynamics in Omicron SARS-CoV-2 Breakthrough Infection | Emerging Microbes & Infections | 8.4 | 外周血 | SeekOne DD 单细胞 5′转录组 | https://doi.org/10.1080/22221751.2025.2494705 | |
| 2025 | Diverse approaches and sources to derive antitumor T cell for liver cancer: a single-cell sequence based research | Hepatology International | 5.9 | 原发性肝癌 | SeekOne DD 单细胞 5′转录组 + VDJ | https://doi.org/10.1007/s12072-025-10818-2 | |
| 2025 | Single-cell transcriptomic analysis deciphers the inflammatory microenvironment characterized by CXCL9+ fibroblasts and ACKR1+ endothelial cells in immune-related myocarditis | Journal of Translational Medicine | 6.1 | 心肌内膜活检组织 | SeekOne MM 单细胞 3'转录组 | https://doi.org/10.1186/s12967-025-06551-x | |
| 2025 | FK506 prolongs corneal allograft survival and prevents dendritic cell infiltration in an MDSC-dependent manner | American Journal of Transplantation | 8.2 | 角膜移植物 | 其他 | https://doi.org/10.1016/j.ajt.2025.05.018 | |
| 2025 | Single-cell transcriptome analysis profiles cellular and molecular alterations in aortic tissue from patients with Behçet’s syndrome | Rheumatology | 4.4 | 主动脉组织标本 | SeekOne MM 单细胞 3'转录组 | https://doi.org/10.1093/rheumatology/keaf252 | |
| 2025 | Dissecting the tumor microenvironment in primary breast angiosarcoma: insights from single‑cell RNA sequencing | Breast Cancer Research | 5.6 | 原发性乳腺血管肉瘤和浸润性乳腺癌的肿瘤样本 | SeekOne DD 单细胞全序列转录组 | https://doi.org/10.1186/s13058-025-02022-9 | |
| 2025 | Identification of Schwann Cells in Human Intracranial Arteries: Potential Regulatory Role in Atherosclerotic Plaque Progression | Advanced Science | 14.1 | 人颅内动脉 | SeekOne DD 单细胞 3′转录组 | https://doi.org/10.1002/advs.202503033 | |
| 2025 | Single-cell transcriptomic analysis deciphers the inflammatory microenvironment characterized by CXCL9+ fibroblasts and ACKR1+ endothelial cells in immune-related myocarditis | Journal of Translational Medicine | 7.5 | 心肌内膜 | SeekOne MM 单细胞 3'转录组 | https://doi.org/10.1186/s12967-025-06551-x | |
| 2025 | Mechanical force‑induced oncostatin M secretion by Jun‑positive neutrophils promotes craniofacial bone regeneration for midface hypoplasia treatment | Stem Cell Research & Therapy | 7.3 | 小鼠的颧上颌缝 | SeekOne MM 单细胞 3'转录组 | https://doi.org/10.1186/s13287-025-04458-4 | |
| 2025 | Targeting AKR1B1 inhibits metabolic reprogramming toreverse systemic therapy resistance inhepatocellular carcinoma | Signal Transduction and Targeted Therapy | 52.7 | 药物敏感和耐药的肝癌细胞系（HCC细胞系） | SeekOne DD 单细胞全序列转录组 | https://doi.org/10.1038/s41392-025-02321-9. | |
| 2024 | Macro CD5L+ deteriorates CD8+T cells exhaustion and impairs combination of Gemcitabine-Oxaliplatin-Lenvatinib-anti-PD1 therapy in intrahepatic cholangiocarcinoma | Nature Communications | 16.6 | 小鼠对照/肝内胆管癌模型 | SeekOne MM 单细胞 3'转录组 | https://doi.org/10.1038/s41467-024-44795-1 | 2024年1月20日，复旦大学樊嘉、周俭、施国明和中国科学院神经科学研究所孙怡迪共同通讯在Nature Communications 发表题为“Macro CD5L+ deteriorates CD8+T cells exhaustion and impairs combination of Gemcitabine-Oxaliplatin-Lenvatinib-anti-PD1 therapy in intrahepatic cholangiocarcinoma”的研究论文。该研究通过scRNA-seq和T细胞受体（TCR）测序表征接受吉西他滨（gemcitabine）联合奥沙利铂（oxaliplatin）、仑伐替尼（lenvatinib）和抗PD1抗体联合治疗（GOLP）前后的肝内胆管癌（iCCA）患者在肿瘤微环境的细胞和分子动力学图谱，研究发现高比例的CD8 GZMB+、CD8+和低比例的Macro CD5L+预示着良好的治疗反应，在反应较差的患者中，CD8 GZMB+和CD8+增殖比例增加，但CD8 GZMK+比例在治疗后降低，Macro CD5L-CD8 GZMB+串扰升高CD8 GZMB+中CTLA4而降低疗效。寻因生物在本研究中主要提供SeekOne®平台的scRNA-seq验证CTLA4是未来临床中可以逆转GOLP耐药性的潜在靶点。 查看解读 |
| 2024 | Unveiling Major Histocompatibility Complex-mediated Pan-Cancer Immune Features by Integrated Single-Cell and Bulk RNA Sequencing | Cancer Letters | 9.1 | 结直肠癌 | SeekOne DD 单细胞 3′转录组 | https://doi.org/10.1016/j.canlet.2024.217062 | |
| 2024 | Single-cell transcriptomic profiling unveils insights into ovarian fibrosis in obese mice | Biology Direct | 5.7 | 小鼠卵巢组织 | SeekOne MM 单细胞 3'转录组 | https://doi.org/10.1186/s13062-024-00496-9 | |
| 2024 | Overcoming tyrosine kinase inhibitor resistance in lung cancer brain metastasis with CTLA4 blockade | Cancer Cell | 48.8 | 人肺癌脑转移（LCBM）样本 | SeekOne MM 单细胞 3'转录组 | https://doi.org/10.1016/j.ccell.2024.09.012 | |
| 2024 | Activation of NOD1 on tumor - associated macrophages augments CD8 + T cell–mediated antitumor immunity in hepatocellular carcinoma | Science Advances | 11.7 | HCC 肿瘤中分离的 CD45 免疫细胞 | 其他 | https://doi.org/10.1126/sciadv.adp8266 | |
| 2025 | Individualized patient tumor organoids faithfully preserve human brain tumor ecosystems and predict patient response to therapy | Cell Stem Cell | 19.8 | 原发性中枢神经系统肿瘤和不同来源的脑转移瘤患者的肿瘤组织，以及与肿瘤组织共培养的人诱导多能干细胞来源的大脑类器官细胞 | SeekOne MM 单细胞 3'转录组 | https://doi.org/10.1016/j.stem.2025.01.002 | |
| 2025 | Methionine intervention induces PD-L1 expression to enhance the immune checkpoint therapy response in MTAP-deleted osteosarcoma | Cell Reports Medicine | 11.7 | 新鲜的骨肉瘤组织（包括原发性肿瘤病灶、转移病灶）的单细胞 | SeekOne DD 单细胞 3′转录组 | https://doi.org/10.1016/j.xcrm.2025.101977 | |
| 2025 | nhaled PAMAM-based nano-formulation prolonged lung retention for alleviating pulmonary inflammation of COPD | Materials Today Bio | 8.7 | 小鼠肺 | SeekOne DD 单细胞 3′转录组 | https://doi.org/10.1016/j.mtbio.2025.101845 | |
| 2025 | Resolving the spatial organization of fetal liver hematopoiesis by SeekSpace | Cell Regeneration | 4 | 小鼠胎儿肝脏组织 | SeekSpace 单细胞空间转录组 | https://doi.org/10.1186/s13619-025-00234-0 | |
| 2025 | Single-Cell Atlas Reveals Tumorigenic Profiles and Immune Dynamics of Adrenal Incidentalomas | Advanced Science | 14.3 | 肾上腺皮质腺瘤 | 其他 | https://doi.org/10.1002/advs.202413493 | 2025年4月，上海交通大学张超团队，东方肝胆医院刘冰团队和山东大学齐鲁医院赵汝星团队合作在《Advanced Science》上发表文章Single-Cell Atlas Reveals Tumorigenic Profiles and Immune Dynamics of Adrenal Incidentalomas，构建了一个全面的、器官特异性的肾上腺肿瘤 scRNA-seq 图谱。该图谱包括 11 例原发性 AI 患者的样本。此外，还纳入了公开可用的单细胞数据集，包括 2 例胎儿肾上腺对照样本、15 例 NB 样本和 4 例 PCC 样本及其瘤周组织。通过利用这些多样且无偏的样本，对患者进行分层，并识别出不同肾上腺肿瘤亚型的疾病特异性标志物。此外，为了进一步阐明影响 AI 中激素分泌和肿瘤间微环境的因素，还整合了批量 RNA-seq 数据和多重免疫荧光数据。尽管大多数 AI 样本为良性，但本研究代表了迄今为止最大规模的单细胞 AI 采样工作，涵盖了广泛的 AI 特征。 查看解读 |
| 2025 | CLDN4 palmitoylation promotes hepatic-to-biliary lineage transition and lenvatinib resistance in hepatocellular carcinoma | Cell Reports Medicine | 10.6 | 肝细胞癌 | SeekOne DD 单细胞 3′转录组 | https://doi.org/10.1016/j.xcrm.2025.102208 | |
| 2023 | Single-cell dynamics of liver development in postnatal pigs | Science Bulletin | 18.9 | 猪肝脏 | SeekOne MM 单细胞 3'转录组 | https://doi.org/10.1016/j.scib.2023.09.021 | |
| 2023 | NADase CD38 is a key determinant of ovarian aging | Nature aging | 16.6 | 小鼠卵巢 | SeekOne DD 单细胞 3′转录组 | https://doi.org/10.1038/s43587-023-00532-9 | 2023年12月，郑州大学第一附属医院孙莹璞/杨庆岭团队在《Nature Aging》发表题为《NADase CD38 is a key determinant of ovarian aging》的文章。该文章结合bulk RNA-seq和ScRNA-seq以及分子实验揭示卵巢衰老早于其他器官，表现为炎症通路基因表达上调。炎症诱导NADase CD38表达上调，导致烟酰胺腺嘌呤二核苷酸 (NAD+) 水平显著下降，调节卵巢衰老。CD38基因敲除可延缓小鼠卵巢衰老、提高小鼠生育力；此外，利用CD38 小分子抑制剂78c处理中年小鼠可提高卵巢NAD+水平，改善卵母细胞质量提高，提高生育力。寻因生物在本研究中主要提供SeekOne® DD平台的ScRNA-seq技术。现在一起了解这篇文章吧。 查看解读 |
| 2024 | Single-cell profiling of the pig cecum at various developmental stages | Zoological Research | 4.9 | 猪盲肠 | SeekOne MM 单细胞 3'转录组 | https://doi.org/10.24272/j.issn.2095-8137.2023.007 | |
| 2024 | CCDC66 mutations are associated with high myopia through affected cell mitosis | J Med Genet | 3.5 | 视网膜 | 其他 | https://doi.org/10.1136/jmg-2023-109434 | |
| 2024 | High expression of PLA2G2A in fibroblasts plays a crucial role in the early progression of carotid atherosclerosis | Journal of Translational Medicine | 6.1 | 颈动脉斑块 | SeekOne DD 单细胞 3′转录组 | https://doi.org/10.1186/s12967-024-05679-6 | |
| 2025 | Blockade of purine metabolism reverses macrophage immunosuppression and enhances anti-tumor immunity in non-small cell lung cancer | Drug Resistance Updates | 15.8 | 肺癌/癌旁巨噬细胞 | SeekOne DD 单细胞 5′转录组 | https://doi.org/10.1016/j.drup.2024.101175 | |
| 2025 | Smad2 Cooperating with TGIF2 Contributes to EMT and Cancer Stem Cells Properties in Pancreatic Cancer via Co-Targeting SOX2 | International Journal of Biological Sciences | 8.2 | 胰腺癌 | 其他 | https://doi.org/10.7150/ijbs.102381 | |
| 2025 | Novel Lysosomal-Associated Transmembrane Protein 4B-Positive Stem-Like Cell Subpopulation Characterizes High-Risk Colorectal Cancer Subtypes | MedComm | 10.7 | 结直肠癌及邻近组织 | SeekOne DD 单细胞 3′转录组 | https://doi.org/10.1002/mco2.70284 | |
| 2023 | Allogenic and autologous anti-CD7 CAR-T cell therapies in relapsed or refractory T-cell malignancies | Blood Cancer Journal | 12.8 | PBMC | SeekOne DD 单细胞 5′转录组 | https://doi.org/10.1038/s41408-023-00822-w | 2023年4月，华中科技大学血液病学研究所梅恒团队在《Blood Cancer Journal》（IF=12.8）发表了题为《Allogenic and autologous anti-CD7 CAR-T cell therapies in relapsed or refractory T-cell malignancies》的文章。本文研究了自体和异体来源的CAR-T在青少年和成人复发性或难治性（r/r）T细胞恶性肿瘤中的安全性和有效性，并利用单细胞测序揭示了CAR-T细胞输注后患者免疫重建情况及异体CAR-T细胞长期存活机制。寻因生物在本研究中主要提供了5’单细胞转录组测序的工作。下面一起了解一下这篇文章吧。 查看解读 |
| 2023 | Corticotropin-Releasing Hormone: A Novel Stimulator of Somatolactin in Teleost Pituitary Cells | Cells（2区） | 5.1 | 垂体细胞 | SeekOne DD 单细胞 3′转录组 | https://doi.org/10.3390/cells12242770 | |
| 2024 | IGFBP1a is a nutrient deficient response factor that can inhibit fish reproduction through the hypothalamus-pituitary-ovary axis | Biology of Reproduction | 3.1 | 垂体细胞 | SeekOne DD 单细胞 3′转录组 | https://doi.org/10.1093/biolre/ioae009 | |
| 2024 | Immunoglobin attenuates fulminant myocarditis by inhibiting overactivated innate immune response | British Journal of Pharmacology | 6.8 | 心脏组织中的 CD45⁺免疫细胞 | SeekOne DD 单细胞 3′转录组 | https://doi.org/10.1111/bph.17372 | |
| 2025 | Single-cell transcriptome reveals three types of adipocytes associated with intramuscular fat content in pigs | Genomics | 3.4 | 成年猪背最长肌 | SeekOne MM 单细胞 3'转录组 | https://doi.org/10.1016/j.ygeno.2025.110998 | |
| 2025 | Cholecystokinin (CCK) Is a Mediator Between Nutritional Intake and Gonadal Development in Teleosts | Cells | 5.1 | 草鱼的下丘脑细胞、垂体细胞 | SeekOne DD 单细胞 3′转录组，SeekSoul Online云平台 | https://doi.org/10.3390/cells14020078 | |
| 2025 | Hydroxychloroquine cures autoimmune myocarditis by inhibiting the innate immune system via the C-X-C motif chemokine ligand 16 and C-X-C motif receptor 6 axis between macrophages and T cells | British Journal of Pharmacology | 6.8 | 小鼠心脏 | SeekOne MM 单细胞 3'转录组 | https://doi.org/10.1111/bph.70028 | |
| 2025 | CD73 inhibitor AB680 suppresses glioblastoma in mice by inhibiting purine metabolism and promoting P2RY12+ microglia transformation | Acta Pharmacologica Sinica | 8.4 | 颅内 G422 TN-GBM 肿瘤 | SeekOne DD 单细胞 3′转录组 | https://doi.org/10.1038/s41401-025-01585-9 | |
| 2025 | CD73 inhibitor AB680 suppresses glioblastoma in mice by inhibiting purine metabolism and promoting P2RY12+ microglia transformation | Acta Pharmacologica Sinica | 8.4 | 颅内 G422 TN-GBM 肿瘤 | SeekOne DD 单细胞 3′转录组 | https://doi.org/10.1038/s41401-025-01585-9 | |
| 2025 | OTUD1 exacerbates sepsis-associated encephalopathy by promoting HK2 mitochondrial release to drive microglia pyroptosis | Journal of Neuroinflammation | 10.1 | 盲肠结扎穿孔（CLP）模型小鼠和假手术小鼠的海马组织单细胞悬液 | SeekOne DD 单细胞 3′转录组 | https://doi.org/10.1186/s12974-025-03480-w | |
| 2025 | OTUD1 exacerbates sepsis-associated encephalopathy by promoting HK2 mitochondrial release to drive microglia pyroptosis | Journal of Neuroinflammation | 10.1 | 盲肠结扎穿孔（CLP）模型小鼠和假手术小鼠的海马组织单细胞悬液 | SeekOne DD 单细胞 3′转录组 | https://doi.org/10.1186/s12974-025-03480-w | |
| 2024 | The landscape of RNA-binding proteins in mammalianspermatogenesis | science | 44.7 | 小鼠睾丸细胞 | SeekOne DD 单细胞全序列转录组 | https://doi.org/10.1126/science.adj8172 | 2024年8月29日，南京医科大学郑科、林明焰、郭雪江共同通讯在Science在线发表题为“The landscape of RNA-binding proteins in mammalian spermatogenesis”的研究论文，该研究揭示了哺乳动物精子发生中RNA结合蛋白的分子景观。该研究为与精子发生和男性不育相关的RNA结合蛋白提供了全面和丰富的资源，并证明了非结构域元件在调控RNA和精子发生中的功能意义，突显了该资源在解码男性生育的遗传和分子基础方面的潜在宽广而重要的价值。寻因生物SeekOne® DD 单细胞全序列技术助力该研究小鼠睾丸的单细胞相关实验，确定了小鼠睾丸有丝分裂生殖细胞的组成。 查看解读 |
| 2025 | Joint analysis of single-cell RNA sequencing and bulk transcriptome reveals the heterogeneity of the urea cycle of astrocytes in glioblastoma | Neurobiology of Disease | 5.1 | 3 例胶质母细胞瘤患者的癌旁组织和肿瘤组织细胞 | SeekOne DD 单细胞 3′转录组 | https://doi.org/10.1016/j.nbd.2025.106835 | |
| 2025 | Integrating microbial GWAS and single cell transcriptomics reveals associations between host cell populations and the gut microbiome | Nature Microbiology | 20.5 | 肝、胰腺、肺、肠等 | SeekOne DD 单细胞 3′转录组 | https://doi.org/10.1038/s41564-025-01978-w | 2025年4月7日，温州医科大学眼视光医院苏建忠团队联合华中科技大学陈卫华团队共同通讯《Nature Microbiology》发表题为《Integrating microbial GWAS and single cell transcriptomics reveals associations between host cell populations and the gut microbiome》的研究论文。为突破宿主–微生物互作研究的解析瓶颈，研究团队开发了创新性算法框架 scBPS，首次实现了微生物GWAS与人类多器官单细胞转录组的整合分析。通过系统性筛选，研究揭示了多个菌属与特定细胞群体之间的高特异性互作关系，尤其指出 Collinsella 可通过调控中央静脉肝细胞的胆固醇代谢，参与宿主代谢性疾病的调控过程。北京寻因生物在本项目中提供了专业的单细胞3‘端转录组测序服务-SeekOne® DD平台，确保研究团队获得高质量的单细胞转录组数据。 查看解读 |
| 2025 | Single-cell and spatial RNA sequencing identify divergent microenvironments and progression signatures in early- versus late-onset prostate cancer | Nature Aging | 17 | 前列腺癌 | SeekOne DD 单细胞 3′转录组 | https://doi.org/10.1038/s43587-025-00842-0 | |
| 2025 | The Hypoxia-Associated High-Risk Cell Subpopulation Distinctly Enhances the Progression of Glioma | Advanced Science | 14.3 | 胶质瘤 | 其他 | https://doi.org/10.1002/advs.202416231 | |
| 2025 | YY1 enhances HIF-1α stability in tumor-associated macrophages to suppress antitumor immunity of prostate cancer in mice | Nature Communications | 15.7 | 小鼠皮下肿瘤单细胞悬液 | SeekOne DD 单细胞 3′转录组 | https://doi.org/10.1038/s41467-025-61560-0 | |
| 2025 | Fibroblast reprogramming in the dura mater of NTG-induced migraine-related chronic hypersensitivity model drives monocyte infiltration via Angptl1-dependent stromal signaling | The Journal of Headache and Pain | 7.3 | 小鼠硬脑膜组织 | SeekOne DD 单细胞 3′转录组 | https://doi.org/10.1186/s10194-025-02058-4 | |
| 2022 | Single-cell profiling of the microenvironment in decidual tissue from women with missed abortions | Fertility and Sterility | 6.7 | 蜕膜组织 | SeekOne DD 单细胞 3′转录组 | https://doi.org/10.1016/j.fertnstert.2022.12.016 | |
| 2024 | APOE ε4–associated downregulation of the IL-7/IL-7R pathway in effector memory T cells: Implications for Alzheimer's disease | Alzheimers Dement | 13 | PBMC | SeekOne MM 单细胞 3'转录组 | https://doi.org/10.1002/alz.14173 | |
| 2024 | APOE ε4–associated downregulation of the IL-7/IL-7R pathway in effector memory T cells: Implications for Alzheimer's disease | Alzheimers Dement | 13 | PBMC | SeekOne MM 单细胞 3'转录组 | https://doi.org/10.1002/alz.14173 | |
| 2025 | Single-cell profiling reveals a reduced epithelial defense system, decreased immune responses and the immune regulatory roles of different fibroblast subpopulations in chronic atrophic gastritis | Journal of Translational Medicine | 6.1 | 慢性萎缩性胃炎 | SeekOne DD 单细胞 3′转录组 | https://doi.org/10.1186/s12967-025-06150-w | |
| 2025 | Oxygen/sulfate radicals-generating CaS2 O8 nanosonosensitizers induce PAN‐optosis and calcium overload for enhanced peritoneal metastasis immunotherapy | Science Bulletin | 18.8 | 结肠腺/胃癌细胞系 | SeekOne DD 单细胞 5′转录组 | https://doi.org/10.1016/j.scib.2025.03.015 | |
| 2025 | Oxygen/sulfate radicals-generating CaS2 O8 nanosonosensitizers induce PAN‐optosis and calcium overload for enhanced peritoneal metastasis immunotherapy | Science Bulletin | 18.8 | 结肠腺/胃癌细胞系 | SeekOne DD 单细胞 5′转录组 | https://doi.org/10.1016/j.scib.2025.03.015 | |
| 2025 | Single‑cell analysis reveals distinct immune characteristics of hepatocellular carcinoma in HBV‑positive vs. HBV‑negative cases | Molecular and Clinical Oncology | 1.4 | HBV 阳性和 HBV 阴性肝细胞癌患者的新鲜肿瘤 | SeekOne DD 单细胞 3′转录组 | https://doi.org/10.3892/mco.2025.2871 | |
| 2025 | Glucagon-like peptide-1 receptor signaling activation in alveolar type II cells enhances lung development in neonatal rats exposed to hyperoxia | Redox Biology | 10.7 | 新生大鼠的肺组织（对照组和 GLP-1R 敲低组） | SeekOne DD 单细胞 3′转录组 | https://doi.org/10.1016/j.redox.2025.103586 | |
| 2023 | Exploring the global immune landscape of peripheral blood mononuclear cells in H5N6-infected patient with single-cell transcriptomics | BMC Medical Genomics | 2.7 | PBMC | SeekOne MM 单细胞 3'转录组 | https://doi.org/10.1186/s12920-023-01693-7 | |
| 2025 | Single-cell transcriptomics reveals the mechanisms of lung injury induced by Galt gene editing in mouse | Biochemical and Biophysical Research Communications | 2.5 | 小鼠肺 | SeekOne DD 单细胞 3′转录组 | https://doi.org/10.1016/j.bbrc.2025.151780 | |
| 2024 | Toll-like receptor agonists promote the formation of tertiary lymphoid structure and improve anti-glioma immunity | Neuro-Oncology | 16.4 | 胶质母细胞瘤 | SeekSoul Online云平台 | https://doi.org/10.1093/neuonc/noae167 | |
| 2025 | Glucagon-like peptide-1 receptor signaling activation in alveolar type II cells enhances lung development in neonatal rats exposed to hyperoxia | Redox Biology | 10.7 | 肺组织 | SeekSoul Online云平台 | https://doi.org/10.1016/j.redox.2025.103586 | |
| 2025 | Utilization of donor CLL-1 CAR-T cells for the treatment of relapsed of acute myeloid leukemia following allogeneic hematopoietic stem cell transplantation | Cell Death & Disease | 8.1 | PBMC | SeekSoul Online云平台 | https://doi.org/10.3389/fimmu.2024.1491341 | |
| 2025 | CD151 Promotes Cancer Progression in Triple-Negative Breast Cancer by Inducing EMT through the MAPK Signaling Pathway | Breast Cancer: Targets and Therapy | 3.3 | 乳腺癌 | SeekSoul Online云平台 | https://doi.org/10.2147/bctt.s518760 | |
| 2025 | Inhaled PAMAM-based nano-formulation prolonged lung retention for alleviating pulmonary inflammation of COPD | Mater Today Bio. | 8.7 | 小鼠肺 | SeekSoul Online云平台 | https://doi.org/10.1016/j.mtbio.2025.101845 | |
| 2025 | Dissecting the tumor microenvironment in primary breast angiosarcoma: insights from single-cell RNA sequencing | Breast Cancer Research | 5.6 | 乳腺血管肉瘤，乳腺癌 | SeekSoul Online云平台 | https://doi.org/10.1186/s13058-025-02022-9 | |
| 2022 | A Small-Molecule Cocktails-Based Strategy in Culture of Mesenchymal Stem Cells | Front Bioeng Biotechnol | 5.7 | MSC诱导 类器官 | SeekOne MM 单细胞 3'转录组 | https://doi.org/10.3389/fbioe.2022.819148 | |
| 2023 | Blocking Dectin-1 prevents colorectal tumorigenesis by suppressing prostaglandin E2 production inmyeloid-derived suppressor cells and enhancing IL-22 binding protein expression | Nature Communications | 16.6 | 回/结直肠癌模型 | SeekOne MM 单细胞 3'转录组 | https://doi.org/10.1038/s41467-023-37229-x | 中山大学附属第一医院精准医学研究院研究员唐策及其团队在Nature Communications上发表题为“Blocking Dectin-1 prevents colorectal tumorigenesis by suppressing prostaglandin E2 production in myeloid-derived suppressor cells and enhancing IL-22 binding protein expression”的文章，结合单细胞转录组及多组学技术在小鼠肠道肿瘤模型和CRC患者的组织样本中研究了Dectin-1促进结直肠肿瘤发生的机制，并提示Dectin-1可能是治疗CRC的靶点。北京寻因生物为其提供了单细胞转录组测序服务，寻因SeekOne®MM助力发现Dectin-1-PGE2-IL-22BP轴调控结直肠肿瘤的发生。 查看解读 |
| 2024 | Tumor cells impair immunological synapse formation via central nervous system-enriched metabolite | Cancer Cell | 50.3 | 乳腺癌/癌旁；外周血 | SeekOne DD 单细胞 3′转录组 | https://doi.org/10.1016/j.ccell.2024.05.006 | |
| 2024 | Non-invasive determination of gene expression in placental tissue using maternal plasma cell-free DNA fragmentation characters | Gene | 2.6 | 外周血单核细胞、绒毛膜羊膜、胎盘绒毛、基底蜕膜 | SeekOne MM 单细胞 3'转录组 | https://doi.org/10.1016/j.gene.2024.148789 | |
| 2024 | Single-cell RNA sequencing reveals the role of mitochondrial dysfunction in the cardiogenic toxicity of perfluorooctane sulfonate in human embryonic stem cells | Ecotoxicology and Environmental Safety | 6.2 | 心脏分化过程中胚胎干细胞 | 其他 | https://doi.org/10.1016/j.ecoenv.2024.115945 | |
| 2024 | Gastric Cancer Actively Remodels Mechanical Microenvironment to Promote Chemotherapy Resistance via MSCs-Mediated Mitochondrial Transfer | Advanced Science | 14.3 | 胃癌患者手术前后的肿瘤组织 化疗前后 | SeekOne DD 单细胞 3′转录组 | https://doi.org/10.1002/advs.202404994 | |
| 2024 | Reconstitution of pluripotency from mouse fibroblast through Sall4 overexpression | Nature Communications | 14.4 | 在 SALL4 和 SALL4 + OCT4 重编程过程中不同时间点（第 0、4、7、10 天）的细胞样本 | SeekOne DD 单细胞 3′转录组 | https://doi.org/10.1038/s41467-024-54924-5 | |
| 2025 | Analysis of the effect of ALA-PDT on macrophages in footpad model of mice infected with Fonsecaea monophora based on single-cell sequencing | Open Medicine | 1.7 | 小鼠足垫的皮肤 | SeekOne DD 单细胞 3′转录组 | https://doi.org/10.1515/med-2024-1132 | |
| 2025 | UBE2C mediates follicular thyroid carcinoma invasion and metastasis via K29-Specific vimentin ubiquitination | Cancer Letters | 9.1 | 甲状腺癌 | SeekOne DD 单细胞 3′转录组 | https://doi.org/10.1016/j.canlet.2025.217624 | |
| 2025 | Influenza A virus dissemination and infection leads to tissue resident cell injury and dysfunction in viral sepsis | eBioMedicine | 9.7 | 小鼠肺组织和肝组织 | 其他 | https://doi.org/10.1016/j.ebiom.2025.105738 | |
| 2025 | Activation of the NRF2 signaling pathway mitigates arthrofibrosis by suppressing myofibroblast ferroptosis through oxidative stress regulation | Cell Investigation | 新刊 | 膝关节滑膜组织 | 其他 | https://doi.org/10.1016/j.clnves.2025.100020 |
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